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Specifications
- Antibody type:Primary
- Antigen name:Apurinic/Apyrimidinic Endonuclease
- Clonality:Polyclonal
- Gene ID:328
- Host:Rabbit
- Isotype:IgG
- Reactivity:Human
- Antigen symbol:APE
- Conjugation:Unconjugated
- ImmunoChemistry:Yes
- Size:100 μg
- Western blot:Yes
- Antigen synonyms:APEX|APEN|REF1|APE|APE1|APX|HAP1
- Storage buffer:Preservative: 0.02% Sodium Azide; Constituents: PBS
- Storage temperature:Keep as concentrated solution. Store at 4 °C short term. For extended storage aliquot and store at –20 °C or below. Avoid freeze-thaw cycles.
- Concentration:0.5 mg/ml
- Immunogen:KLH conjugated synthetic peptides corresponding to amino acids 36-52 and 216-232 of human APE.
- Tested applications:WB
- Purification:Protein G purified
- Cat. no.:89359-896
- Supplier No.:GTX13902
Specifications
About this item
Mammalian apurinic/apyrimidinic endonuclease (APE/ref-1) is a multifunctional, bipartite enzyme that plays an important role in numerous, cellular functions. APE is responsible for repairing abasic sites in DNA and in regulating the redox state of other proteins that play roles in oxidative signaling, transcription factor regulation (Fos, Jun, NFkB, Myb, HIF1 alpha, CREB, Pax), cell cycle control (p53), and apoptosis. Altered levels of APE have also been found in some cancers. The most common form of DNA damage is the creation of abasic sites which are brought about through spontaneous loss or oxidative DNA damage, through chemically initiated hydrolysis (chemotherapy), ionizing radiation, UV irradiation, oxidizing agents, and removal of modified bases by DNA glycosylases.
WB: Use at a concentration of 1 - 2 ?g/ml. Detects a band of approximately 37 kDa (predicted molecular weight: 35 kDa). Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
Type: Primary
Antigen: APE
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human