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Specifications
- Antibody type:Primary
- Antigen name:Phosphodiesterase 11A
- Clonality:Polyclonal
- Gene ID:10846
- Host:Rabbit
- Isotype:IgG
- Reactivity:Human
- Antigen symbol:PDE11A
- Conjugation:Unconjugated
- ImmunoPrecipitation:Yes
- Size:100 μg
- Western blot:Yes
- Antigen synonyms:dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A|PPNAD2 |PDE11A|cyclic nucleotide phosphodiesterase 11A|FLJ23693|cAMP and cGMP cyclic nucleotide phosphodiesterase 11A|MGC133355|MGC133356|phosphodiesterase 11A
- Storage buffer:Stabilization buffer' with 0.02% thimerosal or merthiolate.
- Storage temperature:Keep as concentrated solution. Store at 4oC short term. For extended storage aliquot and store at -20oC or below. Avoid freeze-thaw cycles.
- Concentration:0.7 mg/ml
- Immunogen:Synthetic peptide conjugated to KLH, corresponding to C terminal amino acids 454-468 of Human PDE11A.
- Tested applications:IP, WB
- Purification:Immunogen affinity purified
- Cat. no.:89367-362
- Supplier No.:GTX14624
Specifications
About this item
One of the many phosphodiesterases that compartmentalize and hydrolyze cAMP and cGMP into AMP and GMP is Phosphodiesterase type 11. The human PDE11A contains an open reading frame encoding a 490 amino acid protein (55-56 kDa). The PDE11A has an N-terminus GAF domain homologous to other signaling molecule as found in PDE2, PDE5, PDE6, PDE10, which potentially represents an allosteric cGMP and other small signaling molecules. PDE11A hydrolyzes both cGMP and cAMP; it is sensitive to non-selective PDE inhibitor IBMX as well as zaprinast and dipyrimadole inhibitors that are generally selective for cGMP-specific enzymes. PDE11A expression is diverse and is found in high levels in skeletal muscle, prostate, kidney, liver, pituitary and testis.
IP: Use at a dilution of 1/250. WB: Use at a dilution of 1/500. Detects bands corresponding to at least two PDE11A variants. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
Type: Primary
Antigen: PDE11A
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human