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Specifications
- Antibody type:Primary
- Antigen name:Cyclin-dependent kinase inhibitor 2A (melanoma p16 inhibits CDK4)
- Clonality:Polyclonal
- Gene ID:1029
- Host:Rabbit
- Isotype:IgG
- Reactivity:Human
- Antigen symbol:p14ARF
- Conjugation:Unconjugated
- Size:100 μg
- Western blot:Yes
- Antigen synonyms:CDKN2|MLM|INK4|p16INK4a|p16|p16INK4|p19|p14|p19Arf|CDK4I|INK4a|p14ARF|CMM2|ARF|MTS1|TP16
- Storage temperature:Keep as concentrated solution. Store at 4 °C short term. For extended storage aliquot and store at –20 °C or below. Avoid freeze-thaw cycles.
- Concentration:1 mg/ml
- Immunogen:Synthetic peptide: QRLGQQPLPRRPGHDDGQ (Human) (C terminal).
- Tested applications:WB
- Purification:Immunogen affinity purified
- Cat. no.:89367-416
- Supplier No.:GTX14932
Specifications
About this item
The INK4a locus on chromosome 9p21 is frequently affected in human tumors. It encodes two structurally distinct tumor suppressor proteins, p16INK4a and the alternative reading frame protein, ARF (p14ARF in human and P19ARF in mouse). These two proteins interact with the upstream proteins: retinoblastoma protein and p53 tumor suppressors, respectively. Each of these proteins has a role in the senescence of primary cells, activates pathways for cell cycle control and tumor suppression. The p14ARF (or P19ARF in mouse) proteins can induce both G1 and G2 phase arrest in a manner that depends on functional p53. The mouse and human ARF proteins have different functions in tumor suppression; this distinction may contribute to the different levels of tumor proneness of these species.
WB: Use at a dilution of 1/500. Predicted molecular weight: 17 kDa. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
Type: Primary
Antigen: p14ARF
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human