Xestospongin C

Supplier: Enzo Life Sciences

Xestonspongin C is a structurally novel marine alkaloid isolated from the Okinawan sponge Xestospongia sp. It is a potent, cell-permeable inhibitor of IP3 receptor-mediated Ca2+ release (IC50 = 358 nM). However, since xestospongin C also inhibits voltage-dependent Ca2+ and K+ currents at concentrations similar to those which inhibit the IP3 receptor, it can only be regarded as a selective blocker of the IP3 receptor in permeabilized cells and not in cells with intact plasma membranes. Has vasodilatory properties.

Supplier: Abcam

Potent, selective, reversible IP₃ receptor antagonist (IC₅₀ =350 nM). Inhibits IP₃-mediated Ca²⁺ release from ER and SR. 30-Fold selectivity over ryanodine receptor. Inhibits voltage-dependent Ca²⁺ and K⁺ channels at higher concentrations. Cell-permeable.