You searched for: D-erythro-Sphingosine

Supplier: TCI America

CAS Number: 123-78-4
MDL Number: MFCD00036751
Molecular Formula: C18H37NO2
Molecular Weight: 299.50
Purity/Analysis Method: >96.0% (GC)
Form: Crystal
Color: White
Melting point (°C): 74
Specific rotation [a]20/D: -2 deg (C=1, CHCl3)
Storage Temperature: <0°C

Supplier: Enzo Life Sciences

PKC inhibitor

Supplier: Enzo Life Sciences

Common component of cell membranes, often as phosphatidyl conjugates. Is a potent (IC50=1-3 µM) and selective inhibitor of protein kinase C. Inhibition is competitive with diacylglycerol, phorbol dibutyrate and Ca2+ and it also inhibits PKC activation by other lipids. It acts on an equimolar basis with 1,2-dioleoylglycerol and does not affect other kinases such as MLCK and PKA. It is active in intact cells and has been identified as an endogenous constituent in HL-60 cells, neutrophils, rat liver, and brain and mouse tissues. Other activities include inhibition of phosphatidate phosphohydrolase, Na+,K+-ATPase, CTP:phosphocholine cytidylyltransferase, calmodulin-dependent enzymes, binding of factor VII to tissue factor, binding of thyrotropin releasing hormone to its receptor and activation of EGF receptor kinase, phospholipase D and casein kinase II.

Supplier: Thermo Scientific Chemicals

D-erythro-Sphingosine is used to inhibit protein kinase C and calmodulin-dependent enzymes, induces apoptosis. And also used to constituent of cell membranes.