You searched for: DSP (Dithiobis(succinimidyl propionate))

Supplier: TCI America

[Cross-linking Reagent]
CAS Number: 57757-57-0
MDL Number: MFCD00042045
Molecular Formula: C14H16N2O8S2
Molecular Weight: 404.41
Purity/Analysis Method: >97.0% (N)
Form: Crystal
Melting point (°C): 133
Storage Temperature: 0-10°C

Supplier: G-Biosciences

Dithiobis(succinimidyl propionate) Homobifunctional Cross Linker.

Supplier: Thermo Scientific

Thermo Scientific Pierce DSP (Lomant's Reagent) is a water-insoluble, homo-bifunctional N-hydroxysuccimide ester (NHS ester) crosslinker that is thiol-cleavable, primary amine-reactive, and useful for many applications. DSP contains an amine-reactive NHS ester at each end of an 8-carbon spacer arm. NHS esters react with primary amines at pH 7–9 to form stable amide bonds and releasing N-hydroxy-succinimide. Proteins, including antibodies, generally have several primary amines in the side chain of lysine (K) residues and the N-terminus of each polypeptide that are available as targets for NHS ester crosslinking reagents. DSP is non-sulfonated and insoluble in water, so it must first be dissolved in an organic solvent and then added to the aqueous reaction mixture. Because DSP does not possess a charged group, it is lipophilic and membrane-permeable and so useful for intracellular and intramembrane conjugation. A sulfonated analog of DSP (DTTSP) is water soluble. DSS, the non-cleavable analog of the DSP crosslinker is also available for applications that require a stable spacer arm that cannot be cleaved in the presence of reducing agents.