- Type d'anticorps:Primaire
- Nom de l'antigène:Jarid2/Jumonji
- Clonalité:Polyclonal
- Conjugaison:Alexa Fluor® 680
- Hôte:Rabbit
- ImmunoChimie:Yes
- ImmunoFluorescence:Yes
- Isotype:IgG
- Réactivité:Human,Rat
- Western blot:Yes
- Environmentally Preferable:
- Épitope:301-400/1246
- Formulaire:Liquid
- ID de gène:3720
- Synonymes antigène:JMJ|JARID2|Protein Jumonji|Jumonji/ARID domain-containing protein 2
- Modification:Unmodified
- Storage buffer:Aqueous buffered solution containing 0,01 M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol
- Molecular weight:139 kDa
- Température de stockage:Store at −20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Concentration:1 µg/µl
- Température de transport:4 °C
- Immunogène:KLH conjugated synthetic peptide derived from human Jarid2/Jumonji
- Tested applications:ICC
- Purification:Purified by Protein A
- Type de conditionnement:Vial
- Cdt:100 µl
Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis. Acts by modulating histone methyltransferase activity and promoting the recruitment of histone methyltransferase complexes to their target genes. Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells. Does not have histone demethylase activity but regulates activity of various histone methyltransferase complexes. In embryonic stem cells, it associates with the PRC2 complex and inhibits trimethylation of 'Lys-27' of histone H3 (H3K27me3) by the PRC2 complex, thereby playing a key role in differentiation of embryonic stem cells and normal development. In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of 'Lys-9' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases. Also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5. Participates in the negative regulation of cell proliferation Signalling.
Type: Primary
Antigen: Jarid2/Jumonji
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 680
Public Immunogen Range: 301-400/1246
Host: Rabbit
Isotype: IgG
Reactivity: Human, Rat