- Type d'anticorps:Primaire
- Nom de l'antigène:Transcription factor 25
- Clonalité:Polyclonal
- Conjugaison:Alexa Fluor® 750
- Hôte:Rabbit
- ImmunoChimie:Yes
- ImmunoFluorescence:Yes
- Isotype:IgG
- Réactivité:Human,Rat,Mouse
- Western blot:Yes
- Environmentally Preferable:
- Épitope:201-300/676
- Formulaire:Liquid
- ID de gène:22980
- Synonymes antigène:KIAA1049|Transcription factor 25 basic helix loop helix|Hulp1|NULP1|PRO2620|hKIAA1049|TCF25_HUMAN|Nuclear localized protein 1|FKSG26
- Modification:Unmodified
- Storage buffer:Aqueous buffered solution containing 0,01 M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol
- Température de stockage:Store at −20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Concentration:1 µg/µl
- Température de transport:4 °C
- Immunogène:KLH conjugated synthetic peptide derived from human Transcription factor 25
- Purification:Purified by Protein A
- Type de conditionnement:Vial
- Cdt:100 µl
Transcription factor 25 acts as a transcriptional repressor. It has been shown to repress transcription of SRF in vitro and hence may play a role in heart development. Transcription factor 25, is a 676 amino acid protein that plays a role in cell death. A member of the TCF25 family, Nulp1 utilizes its C-terminus to mediate transcriptional repression of SRF in vitro, and interacts with XIAP. Nulp1 localizes primarily to the nucleus but is also found in cytosol. Widely expressed, Nulp1 is found at high levels in embryonic brain and adult heart. The gene encoding Nulp1 maps to human chromosome 16, which encodes over 900 genes and comprises nearly 3% of the human genome. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterised by increasing malfunction with growth. The rare disorder Rubinstein-Taybi syndrome is also associated with chromosome 16, as is Crohn's disease, which is a gastrointestinal inflammatory condition.
Type: Primary
Antigen: Transcription factor 25
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 750
Public Immunogen Range: 201-300/676
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat