- Type d'anticorps:Primaire
- Nom de l'antigène:Jab1
- Clonalité:Polyclonal
- Conjugaison:Alexa Fluor® 647
- Hôte:Rabbit
- ImmunoChimie:Yes
- ImmunoFluorescence:Yes
- Isotype:IgG
- Réactivité:Human
- Western blot:Yes
- Environmentally Preferable:
- Épitope:221-334/334
- Formulaire:Liquid
- ID de gène:10987
- Synonymes antigène:38 kDa Mov34 homolog|CSN5_HUMAN.|SGN 5|MOV 34|Jun activation domain-binding protein|MGC3149|COP9 signalosome subunit 5|JAB 1|MOV34|COP9 constitutive photomorphogenic homolog subunit 5|COPS5|Cop9 subunit 5|COP9 signalosome complex subunit 5|CSN5|SGN5|Jun activation domain binding protein 1|CSN 5|COPS 5|Signalosome subunit 5
- Modification:Unmodified
- Storage buffer:Aqueous buffered solution containing 0,01 M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol
- Molecular weight:37 kDa
- Température de stockage:Store at –20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Concentration:1 µg/µl
- Température de transport:4 °C
- Immunogène:KLH conjugated synthetic peptide derived from human Jab1
- Tested applications:ICC
- Purification:Purified by Protein A
- Type de conditionnement:Vial
- Cdt:100 µl
The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors.
Type: Primary
Antigen: Jab1
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 647
Public Immunogen Range: 221-334/334
Host: Rabbit
Isotype: IgG
Reactivity: Human