- Type d'anticorps:Primaire
- Nom de l'antigène:DAG1 Tyr892
- Clonalité:Polyclonal
- Conjugaison:Alexa Fluor® 750
- Hôte:Rabbit
- ImmunoChimie:Yes
- ImmunoFluorescence:Yes
- Isotype:IgG
- Réactivité:Rat
- Western blot:Yes
- Environmentally Preferable:
- Formulaire:Liquid
- ID de gène:1605
- Synonymes antigène:Dystroglycan 1 dystrophin-associated glycoprotein 1|AGRNR|Dystroglycan|DAG1 Y892|Beta-DG|Alpha Dystroglycan phospho Y892|beta Dystroglycan|p-DAG1Tyr892|Dag1|Dystrophin-associated glycoprotein 1|DAG1 Tyr892|Alpha-DG|DAG|Beta-dystroglycan|156DAG|A3a|DAG1_HUMAN
- Modification:Phosphorylation (Tyr892)
- Storage buffer:Aqueous buffered solution containing 0,01 M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol
- Molecular weight:43 kDa
- Température de stockage:Store at −20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Concentration:1 µg/µl
- Température de transport:4 °C
- Immunogène:KLH conjugated synthetic phosphopeptide derived from human DAG1 around the phosphorylation site of Tyr892
- Tested applications:ICC
- Purification:Purified by Protein A
- Type de conditionnement:Vial
- Cdt:100 µl
Dystroglycan is a laminin binding component of the dystrophin-glycoprotein complex which provides a linkage between the subsarcolemmal cytoskeleton and the extracellular matrix. Dystroglycan 1 is a candidate gene for the site of the mutation in autosomal recessive muscular dystrophies. The dramatic reduction of dystroglycan 1 in Duchenne muscular dystrophy leads to a loss of linkage between the sarcolemma and extracellular matrix, rendering muscle fibres more susceptible to necrosis. Dystroglycan also functions as dual receptor for agrin and laminin-2 in the Schwann cell membrane. The muscle and nonmuscle isoforms of dystroglycan differ by carbohydrate moieties but not protein sequence. Alternative splicing results in multiple transcript variants all encoding the same protein.
Type: Primary
Antigen: DAG1 Tyr892
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 750
Public Immunogen Range:
Host: Rabbit
Isotype: IgG
Reactivity: Rat