- Type d'anticorps:Primaire
- Nom de l'antigène:Spastic paraplegia 3 protein A
- Symbole de l'antigène:SPG3A
- Clonalité:Polyclonal
- Conjugaison:Cy5®
- Hôte:Rabbit
- ImmunoChimie:Yes
- Isotype:IgG
- Réactivité:Human,Rat,Mouse
- Environmentally Preferable:
- Adsorption croisée:No
- Formulaire:liquid
- Synonymes antigène:Spastic paraplegia 3 protein A|Atlastin GTPase 1|ATLA1_HUMAN|Atlastin-1|Atlastin1|SPG3A.|AD FSP|SPG 3A|GBP3|GBP-3|Guanine nucleotide-binding protein 3|atl1|SPG3|FSP1|Brain-specic GTP-binding protein|Brain specic GTP binding protein|Guanylate binding protein 3|hGBP3|HSN1D|GTP-binding protein 3
- Storage buffer:Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
- Température de stockage:Store at 4°C for 12 months
- Concentration:1 μg/μl
- Température de transport:4°C
- Purification:Purified by Protein A
- Cdt:100 µl
Atlastins are Golgi-localized, integral membrane proteins that function as GTPases. The Atlastin proteins, also designated SPG3A and guanylate-binding protein 3, comprise a Dynamin superfamily that plays a role in axonal maintenance. Hereditary spastic paraplegia (HSP) is an inherited neurodegenerative disorder that is characterized by retrograde axonal degeneration. HSP primarily affects long corticospinal neurons and causes spastic lower extremity weakness. Spastin, a microtubule (MT)-severing AAA ATPase, is a binding partner of Atlastin that is involved in membrane dynamics. This Spastin/Atlastin binding may be involved in the biochemical pathway that leads to HSP development. Mutations in the Atlastin gene (SPG3A) account for approximately 10% of all autosomal dominant HSPs, while mutations in the Spastin gene (SPG4) account for almost 40%.
Recommended Dilutions: IF(IHC-P): 1:50-200
Type: Primary
Antigen: SPG3A/Atlastin
Clonality: Polyclonal
Clone:
Conjugation: Cy5®
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat