Anti-GPS1 Rabbit Polyclonal Antibody (Cy5®)

Catalog # BOSSBS-9133R-CY5

Supplier: Bioss

Catalog # BOSSBS-9133R-CY5

Supplier: Bioss

Specifications

Antibody type:
Primary
Antigen name:
G Protein Pathway Suppressor 1
Antigen symbol:
GPS1
Clonality:
Polyclonal
Conjugation:
Cy5®
Host:
Rabbit
ImmunoChemistry:
Yes
Isotype:
IgG
Reactivity:
Human,
Rat,
Mouse
Environmentally Preferable:
Cross adsorption:
No
Form:
liquid
Gene ID:
2873
Antigen synonyms:
COPS1|GPS1|CSN1|Arabidopsis FUS6/COP11 homolog|G protein pathway suppressor 1|MGC71287
Modification:
phospho-Ser474
Storage buffer:
Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
Storage temperature:
Store at –20 °C for 12 months
Concentration:
1 μg/μl
Shipping temperature:
4°C
Purification:
Purified by Protein A
Pk:
100 µl

Specifications

About this item

Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein-and mitogen-activated protein kinase-mediated signal transduction.

Recommended Dilutions: IF(IHC-P): 1:50-200

Type: Primary
Antigen: GPS1
Clonality: Polyclonal
Clone:
Conjugation: Cy5®
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat