Specifications
- Antibody type:Primary
- Antigen name:AKR1C3/DD3
- Clonality:Polyclonal
- Conjugation:Alexa Fluor® 750
- Host:Rabbit
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Isotype:IgG
- Reactivity:Rabbit
- Western blot:Yes
- Environmentally Preferable:
- Epitope:161-270/323
- Form:Liquid
- Gene ID:8644
- Antigen synonyms:Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase|Testosterone 17-beta-dehydrogenase 5|Dihydrodiol dehydrogenase type I|3 alpha hydroxysteroid dehydrogenase type II|3-alpha-HSD type 2|Type IIb 3 alpha hydroxysteroid dehydrogenase|Dihydrodiol dehydrogenase X|AK1C3_HUMAN|Aldo keto reductase family 1 member C3|Trans-1|Dihydrodiol dehydrogenase 3|Indanol dehydrogenase|DDH1|PGFS|DD3|HAKRe|2-dihydrobenzene-1|KIAA0119|2-diol dehydrogenase|brain|Prostaglandin F synthase|hluPGFS|17 beta hydroxysteroid dehydrogenase type 5|17-beta-hydroxysteroid dehydrogenase type 5|AKR1 C3|17-beta-HSD 5|HAKRB|3-alpha-HSD type II|3-alpha-hydroxysteroid dehydrogenase type 2|Chlordecone reductase homolog HAKRb|3-alpha-HSD type II, brain|DDX|HSD17B5|HA1753|17 beta HSD 5|Aldo-keto reductase family 1 member C3|DD-3|AKR1C3|Chlordecone reductase
- Modification:Unmodified
- Storage buffer:Aqueous buffered solution containing 0,01 M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol
- Molecular weight:36 kDa
- Storage temperature:Store at −20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Concentration:1 µg/µl
- Shipping temperature:4 °C
- Immunogen:KLH conjugated synthetic peptide derived from human AKR1C3
- Tested applications:ICC
- Purification:Purified by Protein A
- Pack type:Vial
- Pk:100 µl
Specifications
About this item
DD3 is a unique enzyme that can specifically catalyse the dehydrogenation of trans-benzenedihydrodiol and trans-naphthalenedihydrodiol.Human liver contains isoforms of dihydrodiol dehydrogenase (DD1, DD2, DD3 and DD4), which belong to the aldo-oxo reductase/aldo-keto reductase (AKR) superfamily, have 20Alpha- or 3Alpha-hydroxysteroid dehydrogenase (HSD) activity. DD1 is also designated AKR1C1, DDH or DDH1 while DD2 also can be designated AKR1C2, dDD, BABP or DDH2. AKR1C3 and 3Alpha-HSD are alternate designations for DD3, while DD4 also can be called AKR1C4, CD or CHDR. DD1 and DD2 are 20Alpha-HSDs, whereas DD3 and DD4 are the 3Alpha-HSDs. The multiple human cytosolic dihydrodiol dehydrogenases are involved in the metabolism of xenobiotics, such as polycyclic aromatic hydrocarbons, pesticides and steroid hormones, and are responsible for the reduction of ketone-containing drugs by using NADH or NADPH as a cofactor. The 20Alpha-HSD catalyses the reaction of progesterone to the inactive form 20Alpha-hydroxyprogesterone. The 3Alpha-HSD is a cytosolic, monomeric, NADPH-dependent oxidoreductase that reduces 3-keto-5-dihydrosteroids to their tetrahydro products. DD1 and DD2 are ubiquitously expressed, whereas DD4 mRNA is restricted to the liver.
Type: Primary
Antigen: AKR1C3/DD3
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 750
Public Immunogen Range: 161-270/323
Host: Rabbit
Isotype: IgG
Reactivity: Rabbit