Anti-FAS Mouse Monoclonal Antibody [clone: APO-1-3]
Catalog # PRSI36-167
Supplier: ProSci Inc.
Specifications
- Antibody type:Primary
- Antigen name:Fatty Acid Synthase
- Antigen symbol:FAS
- Clonality:Monoclonal
- Clone:APO-1-3
- Conjugation:Unconjugated
- Flow cytometry:Yes
- Host:Mouse
- ImmunoPrecipitation:Yes
- Isotype:IgG3
- Reactivity:Human
- Western blot:Yes
- Environmentally Preferable:
- Form:Liquid
- Gene ID:355
- Antigen synonyms:FASTM|APO-1|ALPS1A|TNFRSF6|CD95|APT1|FAS1
- Storage buffer:In PBS. Preservative free formulation.
- Storage temperature:Stable for at least 1 year after receipt when stored at -20˚C.
- Concentration:1 mg/ml
- Shipping temperature:-20°C
- Immunogen:Recombinant human Fas.
- Tested applications:FACS, FUNC,
- Purification:>95% (SDS-PAGE)
- Size:50 μg
- Pk:50 µG
Specifications
About this item
Fas (CD95) is a member of the death receptor (DR) family, a subfamily of the tumor necrosis factor receptor superfamily. The formation of the Fas death-inducing signaling complex (DISC) is the initial step of Fas signaling. Activation of procaspase-8 at the DISC leads to the induction of DR-mediated apoptosis. Stimulation of Fas has been also reported to trigger non-apoptotic pathways. It has been shown that membrane-bound FasL is essential for the cytotoxic activity, whereas soluble FasL appears to promote autoimmunity and tumorigenesis via induction of non-apoptotic pathways, in particular NF-kappaB.
Type: Primary
Antigen: FAS
Clonality: Monoclonal
Clone: APO-1-3
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG3
Reactivity: Human