Anti-ORAI1 Rabbit Polyclonal Antibody
PRSI4281
- Antigen name:ORAI calcium release-activated calcium modulator 1
- Antigen symbol:ORAI1
- Clonality:Polyclonal
- Conjugation:Unconjugated
- ELISA:Yes
- Host:Rabbit
- ImmunoChemistry:Yes
- Isotype:IgG
- Reactivity:Human,Mouse
- Western blot:Yes
- Environmentally Preferable:
- Antigen synonyms:ORAI calcium release-activated calcium modulator 1|ORAI1|FLJ14466|CRACM1|calcium release-activated calcium channel protein 1|ORAT1|calcium release-activated calcium modulator 1|TMEM142A|transmembrane protein 142A
- Storage buffer:PBS containing 0.02% sodium azide
- Immunogen:ORAI1 antibody was raised against a 16 amino acid synthetic peptide from near the carboxy terminus of human ORAI1.
- Tested applications:E, WB, IHC
- Purification:Affinity chromatography purified via peptide column
- Size:100 µg
- Pk:100 µG
ORAI1 Antibody: Antigen stimulation of immune cells triggers Ca++ entry through Ca++ release-activated Ca++ (CRAC) channels. ORAI1 is a recently identified four-transmembrane spanning protein that is an essential component of CRAC. A missense mutation in this protein in humans is the cause of one form of hereditary severe combined immune deficiency (SCID) which results in ablated T-cell Ca++ entry. It has been suggested that ORAI1 functions as a highly selective Ca++ plasma membrane channel that is gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca++ sensor.
Type:
Antigen: ORAI1
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse