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Anti-MARCH8 Rabbit Polyclonal Antibody (Alexa Fluor® 750)
Anti-MARCH8 Rabbit Polyclonal Antibody (Alexa Fluor® 750)
Catalog # BOSSBS-9342R-A750
Supplier:  Bioss
Anti-MARCH8 Rabbit Polyclonal Antibody (Alexa Fluor® 750)
Catalog # BOSSBS-9342R-A750
Supplier:  Bioss

Specifications

  • Antibody type:
    Primary
  • Antigen name:
    MARCH8
  • Clonality:
    Polyclonal
  • Conjugation:
    Alexa Fluor® 750
  • Host:
    Rabbit
  • ImmunoChemistry:
    Yes
  • ImmunoFluorescence:
    Yes
  • Isotype:
    IgG
  • Reactivity:
    Human,
    Rat,
    Mouse
  • Western blot:
    Yes
  • Environmentally Preferable:
  • Epitope:
    101-200/291
  • Form:
    Liquid
  • Gene ID:
    220972
  • Antigen synonyms:
    MARCH 8|Membrane-associated RING-CH protein VIII|Membrane associated RING finger protein 8|Membrane associated ring finger C3HC4 8|MIR|c MIR|Cellular modulator of immune recognition|RNF178|Membrane associated RING CH protein VIII|MARCH-VIII|MARCH8|E3 ubiquitin protein ligase MARCH8|MARH8_HUMAN|RING finger protein 178|MARCH VIII|Membrane-associated RING finger protein 8|E3 ubiquitin-protein ligase MARCH8|c-MIR
  • Modification:
    Unmodified
  • Storage buffer:
    Aqueous buffered solution containing 0,01 M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol
  • Storage temperature:
    Store at ‒20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
  • Concentration:
    1 µg/µl
  • Shipping temperature:
    4 °C
  • Immunogen:
    KLH conjugated synthetic peptide derived from human MARCH8
  • Purification:
    Purified by Protein A
  • Pack type:
    Vial
  • Pk:
    100 µl

Specifications

About this item

The RING-type zinc finger motif is present in a number of viral and eukaryotic proteins and is made of a conserved cysteine-rich domain that is able to bind two zinc atoms. Proteins that contain this conserved domain are generally involved in the ubiquitination pathway of protein degradation. MARCH8 (membrane-associated ring finger (C3HC4) 8), also known as MIR or RNF178 (RING finger protein 178), is a 291 amino acid multi-pass membrane protein that localises to vesicle membranes and contains one RING-CH-type zinc finger. Expressed in a variety of tissues, including immature dendritic cells, MARCH8 functions as an E3 ubiquitin ligase that is thought to regulate immune responses by promoting the ubiquitination and subsequent degradation of target proteins, such as B7-2 and CD71.

Type: Primary
Antigen: MARCH8
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 750
Public Immunogen Range: 101-200/291
Host: Rabbit
Isotype: IgG
Reactivity: Human; Mouse; Rat

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