- Antibody type:Primary
- Antigen name:MKK7/ERK7
- Clonality:Polyclonal
- Conjugation:Alexa Fluor® 680
- Host:Rabbit
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Isotype:IgG
- Reactivity:Human
- Western blot:Yes
- Environmentally Preferable:
- Epitope:301-419/419
- Form:Liquid
- Gene ID:5609
- Antigen synonyms:PRKMK7|JNK kinase 2|SAPK kinase 4|MEK 7|SAPKK-4|JNKK2|JNK-activating kinase 2|Dual specificity mitogen-activated protein kinase kinase 7|MEK7|MAPK/ERK kinase 7|Stress-activated protein kinase kinase 4|MAPKK 7|SAPKK4|MKK7|MAPKK7|SKK4|c-Jun N-terminal kinase kinase 2|MAP2K7|MAP kinase kinase 7|JNKK 2|MEK
- Modification:Unmodified
- Storage buffer:Aqueous buffered solution containing 0,01 M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol
- Molecular weight:46 kDa
- Storage temperature:Store at –20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Concentration:1 µg/µl
- Shipping temperature:4 °C
- Immunogen:KLH conjugated synthetic peptide derived from human MKK7
- Tested applications:ICC
- Purification:Purified by Protein A
- Pack type:Vial
- Pk:100 µl
Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by proinflammatory cytokines. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis.
Type: Primary
Antigen: MKK7/ERK7
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 680
Public Immunogen Range: 301-419/419
Host: Rabbit
Isotype: IgG
Reactivity: Human
: VWR Chemicals
: VWR Chemicals
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: VWR Collection
: VWR Collection
: VWR Collection
: VWR Collection
: KIMBERLY CLARK